GD2 targeting CAR T cells for neuroblastoma * • Neuroblastoma represents a significant clinical unmet need in paediatric oncology. ScienceDirect.com GD2 - an overview | ScienceDirect Topics
T-cells are engineered to recognize and kill GD2-expressing cells. This has shown significant promise in clinical trials for pediatric brain tumors. gd2.zip
Found on cancer stem cells in these aggressive subtypes. GD2 targeting CAR T cells for neuroblastoma *
GD2 is considered an ideal target for precision medicine because of its high density on certain tumor cells. Found on cancer stem cells in these aggressive subtypes
GD2 is a , a type of glycosphingolipid found on the surface of cells. It is primarily recognized as a tumor-associated antigen (TAA) because it is highly overexpressed in various cancers—specifically those of neuroectodermal origin—while remaining largely absent in most healthy adult tissues. Biological Structure and Synthesis