In the penultimate Desperate Housewives episode, " Give Me the Blame " (S8E22), terminal patient Karen McCluskey saves Bree Van de Kamp by taking the fall for Alejandro Perez’s murder in court. While the ladies are cleared, the residents face major life changes, including Susan planning her departure from the street and the Scavos reconciling. This emotional episode wraps up the season-long legal plot, with more details available at IMDb . "Desperate Housewives" Give Me the Blame (TV Episode 2012)