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Sepsis is a complex, life-threatening condition caused by a to infection, leading to acute organ dysfunction. It represents a global disease burden with high mortality rates, often ranging from 18% to 50% for patients requiring intensive care. Current Definitions
The international consensus (Sepsis-3) has updated the terminology to reflect a deeper biological understanding:
: The term "severe sepsis" has been eliminated to simplify bedside recognition. Pathophysiology
: A subset of sepsis involving profound circulatory, cellular, and metabolic abnormalities. It is clinically identified by the need for vasopressors to maintain a mean arterial pressure of ≥65is greater than or equal to 65 mmHg and a serum lactate level >2is greater than 2 mmol/L despite adequate fluid resuscitation.
: Life-threatening organ dysfunction identified by an acute change in the SOFA score (Sequential Organ Failure Assessment) of ≥2is greater than or equal to 2 points consequent to an infection.
Sepsis pathophysiology is an intertwined cascade of immune, endothelial, and coagulation dysfunctions: Sepsis—Pathophysiology and Therapeutic Concepts - PMC
Sepsis is a complex, life-threatening condition caused by a to infection, leading to acute organ dysfunction. It represents a global disease burden with high mortality rates, often ranging from 18% to 50% for patients requiring intensive care. Current Definitions
The international consensus (Sepsis-3) has updated the terminology to reflect a deeper biological understanding: Sepsis: Definitions, Pathophysiology and the Ch...
: The term "severe sepsis" has been eliminated to simplify bedside recognition. Pathophysiology Sepsis is a complex, life-threatening condition caused by
: A subset of sepsis involving profound circulatory, cellular, and metabolic abnormalities. It is clinically identified by the need for vasopressors to maintain a mean arterial pressure of ≥65is greater than or equal to 65 mmHg and a serum lactate level >2is greater than 2 mmol/L despite adequate fluid resuscitation. Pathophysiology : A subset of sepsis involving profound
: Life-threatening organ dysfunction identified by an acute change in the SOFA score (Sequential Organ Failure Assessment) of ≥2is greater than or equal to 2 points consequent to an infection.
Sepsis pathophysiology is an intertwined cascade of immune, endothelial, and coagulation dysfunctions: Sepsis—Pathophysiology and Therapeutic Concepts - PMC
